Michael Scofield (Wentworth Miller) es un hombre desesperado en un situación desesperada. Su hermano Lincoln Burrows (Dominic Purcell), condenado a la pena capital está a la espera de ser ejecutado. A pesar de todas las evidencias, Michael cree en su inocencia, por lo que decide robar un banco para dejarse atrapar y ser encarcelado en la misma prisión que su hermano. Su objetivo: escapar juntos.
Scylla (Episodio 1) 8.2
Guionista: Matt Olmstead
Fecha de emisión: 2008-09-01
Duración: 45 min
Sinopsis: Michael has trailed Gretchen/Susan, Whistler and Mahone to L.A. Chaos reigns in SONA while T-Bag, Bellick and Sucre go missing. Lincoln and L.J. continue to stay with Sofia.
Breaking And Entering (Episodio 2) 8.3
Guionista: Zack Estrin
Fecha de emisión: 2008-09-01
Duración: 45 min
Sinopsis: "Breaking & Entering" is the 59th episode of the American television series Prison Break and was shown together with the first episode of its fourth season as a two-hour episode with "Scylla". It was broadcast on September 1, 2008 in the United States on the Fox Network.
Shut Down (Episodio 3) 8.3
Guionista: Nick Santora
Fecha de emisión: 2008-09-08
Duración: 45 min
Sinopsis: Michael attempts to track the cardholder and avoid going back to prison. Wyatt finds new information regarding Sara's whereabouts. Elsewhere, T-Bag uses a new identity to make a new life for himself.
Eagles and Angels (Episodio 4) 8.3
Guionista: Karyn Usher
Fecha de emisión: 2008-09-15
Duración: 45 min
Sinopsis: Michael, Lincoln and Sucre must crash a police benefit to obtain the next card key. Reeling from another death, Sara falls back into an old habit. T-Bag arouses suspicion and runs into some old “friends” his first day on the job.
Safe and Sound (Episodio 5) 7.8
Guionista: Seth Hoffman
Fecha de emisión: 2008-09-22
Duración: 45 min
Sinopsis: Self locates another card hidden in a safe within a secure federal building, as Mahone continues his quest for revenge. Meanwhile, T-Bag's new life may be in jeopardy.
Blow Out (Episodio 6) 8.3
Guionista: Kalinda Vazquez
Fecha de emisión: 2008-09-29
Duración: 45 min
Sinopsis: The entire operation may be in jeopardy when Mahone gets into trouble with the law. Gretchen's sister receives a surprise visitor. The Company may be onto Self. T-Bag continues to raise suspicions at Gate.
Five the Hard Way (Episodio 7) 7.9
Fecha de emisión: 2008-10-06
Duración: 45 min
Sinopsis: Lincoln takes members of the team to Las Vegas where Sucre gets an indecent proposal. Sara learns about Michael’s condition, and Roland pushes his luck too far. Gretchen teams up with T-Bag who makes an offer to Michael he cannot refuse. Meanwhile, the secrets in Whistler’s bird book are finally revealed.
The Price (Episodio 8) 8.3
Guionista: Graham Roland
Fecha de emisión: 2008-10-20
Duración: 45 min
Sinopsis: Lincoln works to retrieve the final card, which is being held by the General. Michael and Self are forced to work with Gretchen. Meanwhile, Roland continues to be berated for losing the transcribing device in Las Vegas.
Greatness Achieved (Episodio 9) 8.9
Guionista: Nick Santora
Fecha de emisión: 2008-11-03
Duración: 45 min
Sinopsis: Wyatt gets a taste of his own medicine, and Mahone finds some resolution. T-Bag scrambles when the police investigate his missing co-worker while Gretchen gets cozy with a Company man. Meanwhile, Michael’s condition continues to worsen, and a team member makes the ultimate sacrifice while planning the underground break-in for Scylla.
The Legend (Episodio 10) 8.4
Guionista: Karyn Usher
Fecha de emisión: 2008-11-10
Duración: 45 min
Sinopsis: Sara is left with no choice but to take Michael to the hospital as his condtion rapidly worsens. Sucre and Lincoln are faced with unknown territory as they are left in charge of the operation. Elsewhere, agent Self makes a surprising ally.
Quiet Riot (Episodio 11) 8.8
Guionista: Seth Hoffman
Fecha de emisión: 2008-11-17
Duración: 45 min
Sinopsis: Michael races against time and his ailing health to break into the Company headquarters to steal Scylla, but the break-in’s success lies with Sucre. Gretchen dresses up for a meeting with the General and one final attempt to get the last card key. T-Bag must make a decision to leave his criminal ways for good.
Selfless (Episodio 12) 8.9
Guionista: Kalinda Vazquez
Fecha de emisión: 2008-11-24
Duración: 45 min
Sinopsis: Sara takes a hostage in a bid to secure Scylla. In the meantime, Michael and Lincoln finally meet the General while one of their members switches allegiance.
Deal Or No Deal (Episodio 13) 8.7
Fecha de emisión: 2008-12-01
Duración: 45 min
Sinopsis: It's up to Michael to hold the gang together after they find out they were betrayed by one of their own. Meanwhile, Gretchen is blackmailed by T-Bag's new partner.
Just Business (Episodio 14) 8.7
Guionista: Graham Roland
Fecha de emisión: 2008-12-08
Duración: 45 min
Sinopsis: Michael, whose condition is deteriorating, winds up in the hands of The Company who promise Lincoln that they can save Michael's life in exchange for a favor. Elsewhere, Gretchen and Self wind up with Scylla and a buyer.
Going Under (Episodio 15) 8.3
Guionista: Zack Estrin
Fecha de emisión: 2008-12-15
Duración: 45 min
Sinopsis: Michael gets medical attention from the most unlikely of places, and Charles Westmoreland returns to help uncover the true meaning of Scylla. Meanwhile, Lincoln and Sucre race to stop Gretchen before Scylla is lost forever.
The Sunshine State (Episodio 16) 8.2
Guionista: Matt Olmstead
Fecha de emisión: 2008-12-22
Duración: 45 min
Sinopsis: Lincoln and his new partners arrive in Miami to recover Scylla from its shocking new owner, and Sara searches for a missing Michael who learns some surprising information about his past. Meanwhile, a double-crossing leads to a death and an arrest in "The Sunshine State."
The Mother Lode (Episodio 17) 8.2
Guionista: Seth Hoffman
Fecha de emisión: 2009-04-17
Duración: 45 min
Sinopsis: Michael and Sara journey to Miami while Lincoln meets with his mother. T-Bag and Self's mission to locate Scylla takes a dramatic turn. The General comes under pressure.
VS. (Episodio 18) 8.3
Fecha de emisión: 2009-04-24
Duración: 45 min
Sinopsis: Michael and Lincoln come to blows over Scylla as Christina sets the wheels in motion for her plan. Meanwhile, Sara receives life-changing news. T-Bag arrives at the Indian Embassy. The General becomes increasingly paranoid.
S.O.B. (Episodio 19) 8.2
Guionista: Karyn Usher
Fecha de emisión: 2009-05-01
Duración: 45 min
Sinopsis: Michael's reunion with Christina is soured when she drops a bombshell regarding Lincoln, and T-Bag grows determined to prove he is worthy of being a member of the Company.
Cowboys and Indians (Episodio 20) 8.3
Guionista: Nick Santora
Fecha de emisión: 2009-05-08
Duración: 45 min
Sinopsis: Pandemonium erupts at the hotel following the assassination, and Christina puts the final pieces of her plan together. Meanwhile, the General makes good on his threat, and Michael is forced to choose between saving either Lincoln or Sara.
Rate of Exchange (Episodio 21) 8.5
Guionista: Zack Estrin
Fecha de emisión: 2009-05-15
Duración: 45 min
Sinopsis: Familiar faces return to help Michael end his quest to bring down The Company once and for all.
Killing Your Number (Episodio 22) 8.8
Guionista: Matt Olmstead
Fecha de emisión: 2009-05-15
Duración: 45 min
Sinopsis: Michael tries to bring down the Company once and for all.