故事讲述近百年来有不少人被外星人TAKEN。在2004年7月的一天，美国国家安全局发现一颗慧星高速的飞向地球，危及地球人安全。全球各国(包括中国)都向该慧星发射导弹欲摧毁之，结果没有任何作用。最后慧星在上图中那个湖边降落，一阵迷雾散开之后，湖边出现4400个不同年代被TAKEN的人，而且他们都完好的保持着各自年代里被TAKEN时的原样。最终当这4400人走向社会时，却发现他们有着超乎常人的特异功能。这些人曾去了哪儿？又怎么回来的？为什么会有特异功能？为什么是4400个人？他们最终会给地球带来怎么的变化？或者这是一个外星人的实验？或者是来自未来的拯救行动？
4400失踪人口 (季节 3)
The New World (1) 7.8
播出日期: 2006-06-11
运行时间: 42 min
概述: Ryland and other government officials are on trial for withholding vital information that they discovered about the returnees when a disturbing sound is heard the courtroom. Tom and Diana, with the help of Gary Navarro, try and track down T.J Kim, who they believe is responsible for the piercing sound heard in the courtroom. Richard and Lily are forced to deal with a now grown Isabelle While Lily also suffers from a rapid aging disease that Shawn is unable to heal. Tom and Diana also investigate a radical organisation called the Nova Group that appears to have ties with Shawn and the 4400 Center.
The New World (2) 8.0
播出日期: 2006-06-11
运行时间: 42 min
概述: Gary Navarro is arrested for the second attempt to assassinate Dennis Ryland. Knowing she is the key to her mother's survival, Isabelle attempts to kill herself by jumping off the 4400 center building only to survive without a scratch. Matthew Ross expresses his displeasure at her actions and tells her of the destiny she is to face. Isabelle is troubled about what Matthew told her, but after a discussion with Shawn she decides it's her choice with what she does with her life. Matthew gives Isabelle a substance that can kill her if it's injected.
Being Tom Baldwin 7.8
播出日期: 2006-06-18
运行时间: 42 min
概述: Tom is accused of murdering TJ Kim. 17 year old Boyd Gelder has the ability to change his appearance whenever he chooses. Meanwhile, Shawn and Isabelle grow closer.
Gone (1) 7.8
播出日期: 2006-06-25
运行时间: 42 min
概述: Someone is targeting young 4400's and Maia gets kidnapped. A mistake from Shawn's past comes back to haunt him. Richard is given a position of authority at the 4400 Center.
Gone (2) 8.0
播出日期: 2006-07-02
运行时间: 42 min
概述: Tom and Diana continue to investigate the disappearance of the 4400 children. Isabelle and Shawn's relationship becomes public.
Graduation Day 7.8
播出日期: 2006-07-09
运行时间: 42 min
概述: Isabelle seeks revenge on the Nova Group after they attack Shawn. Alana confronts the man responsible for killing her husband and son in a car accident nine years ago.
The Home Front 7.5
播出日期: 2006-07-16
运行时间: 42 min
概述: With the help of Dennis Ryland, NTAC track down the remining members of the NOVA group. Nikki pays Shawn a visit.
Blink 7.5
播出日期: 2006-07-23
运行时间: 42 min
概述: Tom and Diana are drugged with a hallucinogen, that was created from oil that was secreted from the hands of a 4400.
The Ballad of Kevin and Tess 7.2
播出日期: 2006-07-30
运行时间: 42 min
概述: Kevin is on the run after horribly mutating due to the promicin experiments. Tom and Diana go to Tess for help. Diana gets what she believes is the flu and discovers something startling.
The Starzl Mutation 7.5
播出日期: 2006-08-06
运行时间: 42 min
概述: Tom and Diana's investigation into a series of gruesome murders leads them to uncover another conspiracy within the government. At the 4400 Center, Shawn receives a gift from another returnee that allows him to see his future.
The Gospel According to Collier 7.8
播出日期: 2006-08-13
运行时间: 42 min
概述: NTAC and the 4400 Center work together to find Jordan Collier. Kyle Baldwin gets a surprising visitor at the state prison.
Terrible Swift Sword 7.5
播出日期: 2006-08-20
运行时间: 42 min
概述: NOVA group members that were in the custody of NTAC escape from jail with outside help from Jordan Collier. Diana tells April about her relationship with Ben. Shawn and Richard learn that Isabelle is working with Dennis Ryland.
Fifty–Fifty 7.2
播出日期: 2006-08-27
运行时间: 42 min
概述: Tom and Diana continue their investigation on Jordan Collier's plan for mankind. Dennis Ryland rejoins NTAC. Isabelle prepares for battle.
季
集 5
集 13
集 13
集 13
集 1