节目会请一些嘉宾来讨论当前政坛和媒体上的事件。与之前节目不同的是，马赫脱口秀请到的嘉宾往往对所讨论问题有比较充分的认识，嘉宾中演员和名人比较少。另外，很多嘉宾是以卫星连线的形式参与的。节目的长度约为一小时，在摄影棚内有观众现场观看，东部时间每周五晚十点直播。节目源自于洛杉矶CBS电视台的第33摄影棚（“Bob Barker摄影棚”）。春季（二月到五月上旬）约播出12集，秋季（八月下旬到十一月）也播出数量相当的集数。由于节目针对的是时事，所以HBO电视台一般在节目间歇的月份不会安排重播，但偶尔如果有一周节目不播的话，会安排重播之前的节目。
播出日期: 2013-01-18
运行时间: 60 min
概述: Guests: Comedian Martin Short, former Governor & Senator Bob Kerrey (D-NE), journalist Rula Jebreal, reporter Michelle Caruso-Cabrera, and former Rep. Steve LaTourette. Topics: The future of the Republicans, gun control, Israeli elections, revolution in Syria, torture, Manti Te'o girlfriend hoax, the media, neither party cares about privacy
播出日期: 2013-01-25
运行时间: 60 min
概述: GOPAC president David Avella; former Vt. Gov. Howard Dean; political strategist Kristen Soltis; House Democratic leader Nancy Pelosi; Sen. Jon Tester (D-Mont).
播出日期: 2013-02-01
运行时间: 60 min
概述: Interview Guests: Alex Gibney, Sam Harris Panelists: Cory Booker, Jackie Kucinich, Eva Longoria Alex Gibney is an American documentary filmmaker. His latest documentary "Mea Maxima Culpa: Silence in the House of God" apparently debuts Feb 4, 2013 on HBO. Sam Harris is a philosopher whose latest book is "Free Will". He blogs at samharris.org and has recently written on the gun control issue. Cory Booker is the mayor of Newark, New Jersey and is a high-profile Democrat. Jackie Kucinich is a reporter covering politics for USA Today and is a frequent guest commentator on MSNBC. Eva Longoria is an American television and film actress, best known for her roles on "The Young and the Restless" and "Desperate Housewives".
播出日期: 2013-02-08
运行时间: 60 min
概述: WikiLeaks founder Julian Assange; editor Tina Brown; journalist Josh Barro; jouralist Martin Bashir; theoretical physicist Lawrence Krauss.
播出日期: 2013-02-15
运行时间: 60 min
概述: Robert Zimmerman; actor Joel McHale; political strategist Donna Brazile; author Jon Meacham; editor Jamie Weinstein.
播出日期: 2013-03-01
运行时间: 60 min
概述: Cybersecurity expert James Lyne; musician Snoop Lion (formerly Snoop Dogg); finance expert Monica Mehta; Lt. Gov. Gavin Newsom (D-CA); political strategist Steve Schmidt.
播出日期: 2013-03-08
运行时间: 60 min
概述: Journalist Charlies LeDuff; author Arianna Huffington; health care expert Avik Roy; former Republican National Committee chair Michael Steele; actor/comic David Cross.
播出日期: 2013-03-15
运行时间: 60 min
概述: Education reformer Michelle Rhee, chef Tom Colicchio, economist Jared Bernstein, former Rep. Tom Davis (R-VA), and TV host Rachel Maddow.
播出日期: 2013-03-22
运行时间: 60 min
概述: Economist Austan Goolsbee; music-business executive Clive Davis; journalist John Feehery; voter registration advocate Maria Teresa Kumar; former Gov. Jim McGreevey (D-NJ).
播出日期: 2013-04-05
运行时间: 60 min
概述: Interview Guest: Sebastian Junger Panelists: Abby Huntsman, Stephen Moore, Bernie Sanders Panel Guest: Zack Kopplin Sebastian Junger is an award-winning Afghanistan war correspondent and filmmaker. His latest project is a film for HBO titled "Which Way Is the Front Line from Here? The Life and Time of Tim Hetherington". Abby Huntsman is a political commentator and host of HuffPost Live. Stephen Moore is an economist, conservative commentator and the author of "Who’s The Fairest of Them All: The Truth About Opportunity, Taxes, and Wealth in America". Bernie Sanders is the independent senator from Vermont. Zack Kopplin is a science education activist.
播出日期: 2013-04-12
运行时间: 60 min
概述: Gun control advocate Colin Goddard; sportscaster Bob Costas; political strategist Stephanie Cutter; economist David Stockman; activist Saru Jayaraman.
播出日期: 2013-04-19
运行时间: 60 min
概述: Tonight's guests are director Brian Levin, gun control advocate Colin Goddard, TV anchor Amy Holmes, columnist & author Nicholas Kristof and author Salman Rushdie.
播出日期: 2013-04-26
运行时间: 60 min
概述: Guests: Donald Borelli, Jimmy Kimmel, John Avlon, Anna Deavere Smith, Robert Traynham.
播出日期: 2013-05-03
运行时间: 60 min
概述: Guests: Jeremy Scahill, Lawrence O'Donnell, Pete Hegseth, Mattie Duppler, Marc Maron.
播出日期: 2013-05-10
运行时间: 60 min
概述: Guests: From "Star Trek: Into Darkness", actor Zachary Quinto; NYT Food & Opinion journalist Mark Bittman; Guardian columnist Glenn Greenwald; MSNBC analyst Joy Reid; National Review journalist Charles Cooke.
播出日期: 2013-05-17
运行时间: 60 min
概述: Guests: Oscar winning director Michael Moore; from "The Hangover Part III", actor/comedian Zach Galifianakis; from "The Cycle", co-host S.E. Cupp; from "Foreign Policy Begins at Home", author Richard Haas; NYT Finance columnist Andrew Ross Sorkin.
播出日期: 2013-05-31
运行时间: 60 min
概述: Guests: Actress and screenwriter Brit Marling; humorist Raul Rudnick; from the Center for American Progress, Neera Tanden; Journalist Michael Isikoff; from "HuffPost Live", producer James Poulos.
播出日期: 2013-06-07
运行时间: 60 min
概述: Guests: Filmmaker & author Tom Shadyac; journalist & author George Packer; GOP strategist Ana Navarro; comedian Dana Gould; author Kevin Williamson.
播出日期: 2013-06-14
运行时间: 60 min
概述: Guests: Ex U.S. Rep. Patrick Kennedy (D-RI); "The Center Holds" author Jonathan Alter; "Gasland Part II" director Josh Fox; "Great Degeneration" author and Harvard professor Niall Ferguson; conservative pollster Kellyanne Conway.
播出日期: 2013-06-21
运行时间: 60 min
概述: Guests: Ex New York Times Op-Eder & Demos Fellow Bob Herbert; first female Saudi filmmaker Haifaa al-Mansour; "Cooked" author Michael Pollan; "Queen of the Turtle Derby" author Julia Reed; Bloomberg Businessweek journalist Josh Green.
播出日期: 2013-06-28
运行时间: 60 min
概述: The Interview: Anthony Leiserowitz is the Director of the Yale Project on Climate Change Communication, which "investigates the psychological, cultural, political, and geographic factors that drive public environmental perception and behavior." Twitter: @ecotone2 The Panel: Kristen Soltis has been described as "the Republican Party's leading millennial pollster" and serves as the Vice President of DC-based opinion research and political communications firm The Winston Group. Twitter: @KSoltisAnderson Dan Neil is a Pulitzer Prize-winning journalist and the author of The Wall Street Journal's "Rumble Seat" column, where he reviews everything from the Aston Martin Rapide S to John Deer's latest Gator. Twitter: @Danneilwsj Horace Cooper is a writer and legal commentator who serves at the Co-Chairman of the National Advisory Board for Project 21: "an initiative of The National Center for Public Policy Research to promote the views of African-Americans whose entrepreneurial spirit, dedication to family and commitment to individual responsibility has not traditionally been echoed by the nation's civil rights establishment." He is also a partner at Monument Communications. Adrian Grenier will join the panel mid-show. He is an actor, filmmaker and entrepreneur who recently produced 'How to Make Money Selling Drugs,' a film exploring the failure of American's drug war. It opens in New York on June 26th and Los Angeles on June 28th and is currently available on demand. Adrian recently penned an editorial for The Huffington Post, calling for the "return a sense of rationality and proportion to a justice system that has spun wildly out of control."
播出日期: 2013-07-12
运行时间: 60 min
概述: Guests: "Hope on a Tightrope" author Dr. Cornel West; "Dirty Jobs" host Mike Rowe; GOP strategist Liz Mair; Daily Caller blogger Matt Lewis.
播出日期: 2013-07-19
运行时间: 60 min
概述: Guests: tba
播出日期: 2013-07-26
运行时间: 60 min
概述: Guests: tba
播出日期: 2013-08-02
运行时间: 60 min
概述: Guests: tba
播出日期: 2013-09-13
运行时间: 60 min
概述: Panellists: Zanny Minton Beddoes, Edwin Lyman, Bill Nye, Michael Steele, Matt Taibbi.
播出日期: 2013-09-20
运行时间: 60 min
概述: Bill's guests are Joy Behar, Billy Crystal, David Frum, Chris Hayes, and Jeremy Seifert.
播出日期: 2013-09-27
运行时间: 60 min
概述: Guests: Carl Hart, Monica Mehta, Jeff Rechner, Robert Reich, Tim Robbins, and Matt Welch.
播出日期: 2013-10-04
运行时间: 60 min
播出日期: 2013-10-11
运行时间: 60 min
播出日期: 2013-10-25
运行时间: 60 min
概述: Interviewee: Maajid Nawaz (ex Islamic radical) Panelists: Rev. Al Sharpton (MSNBC host & author of "Rejected Stone"), Michael Moore (filmmaker), Valerie Plame (co-author of "Blowback") Panel Guest: Richard Dawkins (author of "Appetite for Wonder") Topics: Obamacare's dysfunctional website, perceived strengths of each party, NSA spying on other countries, new evolution finding, Pope Francis, is Islam more dangerous than Christianity?, the minimum wage.
播出日期: 2013-11-01
运行时间: 60 min
概述: Interviewee: Ann Coulter (author) Panelists: Debbie Wasserman Schultz (Rep. D-FL), Neil deGrasse Tyson (scientist), Rob Reiner (filmmaker) Panel Guest: Rob Lowe (actor, "Killing Kennedy") Topics: Obama's lie about current health care plans, Ted Cruz, Sr., women in politics, Rob Lowe as JFK, US embargo against Cuba, Kessler Syndrome, NSA spying, Republicans should appeal to stoners.
播出日期: 2013-11-08
运行时间: 60 min
概述: Interviewee: Billy Binney (NSA whistleblower) Panelists: John Heilemann ("Double Down" co-author), Dr. Victoria DeFrancesco Soto (University of Texas fellow), David Avella (GOPAC President) Panel Guest: Anthony Weiner (Ex-Rep. D-NY) Topics: NSA spying, 2013 elections, Chris Christie as a 2016 Republican presidential nominee, Republican constituents, Tea Party vs. GOP establishment, Anthony Weiner scandal and media coverage of the scandal, Obamacare, Bill de Blasio's victory, commemorating tragedies, self-importance of political authors, hypocrisy of the religious right.
播出日期: 2013-11-15
运行时间: 60 min
概述: Guests: Casey Affleck (actor), Ezra Klein (Washington Post journalist), Reihan Salam (National Review Online blogger), Mattie Duppler (Americans for Tax Reform), Radley Balko (Washington Post journalist).
播出日期: 2013-11-22
运行时间: 60 min
概述: Guests: Wendell Pierce ("Treme", actor), Bob Ehrlich (Ex-Gov. R-MD), Paul Begala (CNN analyst), Katty Kay (BBC America anchor), ...
