节目会请一些嘉宾来讨论当前政坛和媒体上的事件。与之前节目不同的是，马赫脱口秀请到的嘉宾往往对所讨论问题有比较充分的认识，嘉宾中演员和名人比较少。另外，很多嘉宾是以卫星连线的形式参与的。节目的长度约为一小时，在摄影棚内有观众现场观看，东部时间每周五晚十点直播。节目源自于洛杉矶CBS电视台的第33摄影棚（“Bob Barker摄影棚”）。春季（二月到五月上旬）约播出12集，秋季（八月下旬到十一月）也播出数量相当的集数。由于节目针对的是时事，所以HBO电视台一般在节目间歇的月份不会安排重播，但偶尔如果有一周节目不播的话，会安排重播之前的节目。
播出日期: 2019-01-18
运行时间: 60 min
概述: Guests: John Kasich, Marshawn Lynch, Erick Erickson, Barney Frank, Catherine Rampell.
播出日期: 2019-01-25
运行时间: 60 min
概述: Guests: Ann Coulter, Michael McFaul, Joshua Green, Dan Savage, Heather McGhee.
播出日期: 2019-02-01
运行时间: 60 min
概述: Guests: Will Hurd, Bill de Blasio, Peter Hamby, Jon Meacham, Jennifer Rubin.
播出日期: 2019-02-08
运行时间: 60 min
概述: Guests: Chris Christie, Eric Idle, Natasha Bertrand, Jack Kingston, Malcolm Nance.
播出日期: 2019-02-15
运行时间: 60 min
概述: Guests: Mayor Rahm Emanuel, John Legend, Paul Begala, David Frum & Maya Wiley.
播出日期: 2019-02-22
运行时间: 60 min
概述: Guests: Congressman Adam Schiff, Bernard-Henri Lévy, Donna Brazile, Claire McCaskill & Rick Wilson.
播出日期: 2019-03-08
运行时间: 60 min
概述: Guests: Matt Schlapp, Noah Rothman, Jonathan Alter, Mary Katharine Ham, Michael Steele.
播出日期: 2019-03-15
运行时间: 60 min
概述: Guests: Andrew McCabe, Andrew Gillum, John Heilemann, Jon Tester, Jessica Yellin.
播出日期: 2019-03-22
运行时间: 60 min
概述: Guests: Irshad Manji, Larry Charles, Kristen Soltis Anderson, Evelyn Farkas, Rep. Eric Swalwell.
播出日期: 2019-03-29
运行时间: 60 min
概述: Guests: Pete Buttigieg, Preet Bharara, S.E. Cupp, Elissa Slotkin, Andrew Sullivan.
播出日期: 2019-04-05
运行时间: 60 min
概述: Guests: Julian Castro, Chelsea Handler, Danielle Pletka, Gideon Rose, Salman Rushdie.
播出日期: 2019-04-12
运行时间: 60 min
概述: Guests: Seth Abramson, Dave Barry, Cornell Belcher, Wendy R. Sherman, Matt Welch.
播出日期: 2019-04-26
运行时间: 60 min
概述: Guests: Adam Schiff, Bob Costas, John Avlon, Zerlina Maxwell, Grover Norquist.
播出日期: 2019-05-03
运行时间: 60 min
概述: Guests: Jay Inslee, Moby, Bakari Sellers, Bret Stephens, Kara Swisher.
播出日期: 2019-05-10
运行时间: 60 min
概述: Guests: Michael Lewis, Tim Ryan, Nayyera Haq, Van Jones, Matt Lewis.
播出日期: 2019-05-17
运行时间: 60 min
概述: Guests: Fran Lebowitz, Jonathan Metzl, James Kirchick, George Packer, Neera Tanden.
播出日期: 2019-05-31
运行时间: 60 min
概述: Guests: William Weld, John Waters, Kirsten Powers, Jonathan Swan, Lawrence Wilkerson.
播出日期: 2019-06-07
运行时间: 60 min
概述: Guests: Andrew Yang, Bret Easton Ellis, Charles Blow, Katie Porter, Clint Watts.
播出日期: 2019-06-14
运行时间: 60 min
概述: Guests: George Will, Martin Short, Eliot Spitzer, Charlie Sykes, Bari Weiss.
播出日期: 2019-06-21
运行时间: 60 min
概述: Guests: Allan Lichtman, Dr. Debra Soh, Thom Hartmann, Liz Mair, Dan Savage.
播出日期: 2019-06-28
运行时间: 60 min
概述: Guests: Tulsi Gabbard, Seth MacFarlane, Max Brooks, Adam Gopnik, Joy Reid.
播出日期: 2019-08-02
运行时间: 60 min
概述: Guests: New York Congressman Hakeem Jeffries, Democratic Presidential candidate Marianne Williamson, journalist Josh Barro, former Governor of Michigan Jennifer Granholm, radio host Buck Sexton.
播出日期: 2019-08-09
运行时间: 60 min
概述: Guests: Former Governor of Virginia Terry McAuliffe, NBC News Chief Foreign Correspondent Richard Engel, author Tom Nichols, columnist Catherine Rampell, former White House Communications Director Anthony Scaramucci.
播出日期: 2019-08-16
运行时间: 60 min
概述: Guests: Sen. Sheldon Whitehouse, Carl Hulse, Betsy Woodruff, Rick Wilson & Michael Render
播出日期: 2019-08-23
运行时间: 60 min
概述: Guests: Rep. Katie Porter, Sen. Heidi Heitkamp, Michael Smerconish, Eric Klinenberg & Kevin D. Williamson
播出日期: 2019-09-06
运行时间: 60 min
概述: Guests: Rep. Joe Walsh, Christina Hoff Sommers, Rep. John Delaney, María Teresa Kumar & Matt Welch
播出日期: 2019-09-13
运行时间: 60 min
概述: Guests: Michael Moore, Krystal Ball, Michael Steele, Fernand Amandi & Bari Weiss
播出日期: 2019-09-20
运行时间: 60 min
概述: Guests: Amb. Samantha Power, Heather McGhee, Tim Naftali, Andrew Sullivan & Sarah Haider
播出日期: 2019-09-27
运行时间: 60 min
概述: Guests: Gina McCarthy, Linette Lopez, Noah Rothman, Salman Rushdie & Barney Frank
播出日期: 2019-10-11
运行时间: 60 min
概述: Guests: Howard Stern, Sen. Amy Klobuchar, Ben Domenech, Shawna Thomas & John Heilemann
播出日期: 2019-10-18
运行时间: 60 min
概述: Guests: Susan Rice, Neil deGrasse Tyson, Sam Stein, Danielle Pletka & Thomas Chatterton Williams
播出日期: 2019-10-25
运行时间: 60 min
概述: Guests: Zach Galifianakis, Chris Cuomo, Rep. Elissa Slotkin, Dan Carlin, Donny Deutsch.
播出日期: 2019-11-01
运行时间: 60 min
概述: Guests: Ronan Farrow, Rick Stengel, Christina Bellantoni, Dennis Prager, & Dr. Jay Gordon.
播出日期: 2019-11-08
运行时间: 60 min
概述: Guests: Judd Apatow, Gov. Steve Bullock, Rahm Emanuel, Steve Schmidt, and Judge Judy.
播出日期: 2019-11-15
运行时间: 60 min
概述: First interview: Sen. Sherrod Brown. On the panel: Ian Bremmer, Donna Brazile, Frank Bruni. Second interview: Jaime Harrison.
