本片为美国时代华纳公司旗下的Cartoon Network推出的动画长篇，1998年播映了完整的动画片。位于美国的小镇村里来了一位神秘的尤教授，秉着一颗让世界更美好的心，尤教授通过科学实验，制造出了三个拥有超自然力量的完美女孩——泡泡、毛毛、花花，泡泡比较天真和乐天开朗，毛毛比较暴躁和爱美，花花则是领袖及代言人，她们三人组成了惩奸除恶的“飞天小女警”组合。在小镇村内设有专线供村民呼叫飞天小女警来寻求帮助，飞天小女警的主要任务就是与魔猴啾啾（Mojo jojo）、毛茸怪兽（Fuzzy Lumpkins）、阿米巴帮（the Amoeba boys）、“他”（Him），以及蟑螂教练等一班坏蛋们斗智斗力。
播出日期: 2000-07-28
运行时间: 12 min
概述: Old supervillains break out of the retirement home, and the Powerpuff Girls get old superheroes out of retirement to beat them.
播出日期: 2000-07-28
运行时间: 12 min
概述: Bubbles and Buttercup do Blossom's hair, but when it gets tangled they give Blossom a bad hair day.
播出日期: 2000-08-18
运行时间: 12 min
概述: The Professor gets a new job, and the Utonium family moves to the Town Of Citysville. The Professor loves it, but the girls don't and are having a hard time adjusting to the new changes.
播出日期: 2000-08-18
运行时间: 12 min
概述: The Professor has to go out to an award's ceremony. He forgets to call the babysitter so he calls the Mayor who calls up Mojo Jojo to babysit.
播出日期: 2000-09-08
运行时间: 21 min
概述: The Professor gets a new job, and the Utonium family moves to the Town Of Citysville. The Professor loves it, but the girls' don't and are having a hard time to adjust to the new changes.
播出日期: 2000-09-15
运行时间: 12 min
概述: Bubbles has problems seeing, so she's forced to wear glasses.
播出日期: 2000-09-15
运行时间: 12 min
概述: Princess buys Townsville and makes crime legal.
播出日期: 2000-09-22
运行时间: 12 min
概述: Ms. Keane assigns pet duty since it's Friday. The Powerpuff Girls volunteer, but she chooses Mitch to take care of Twiggy, the class hamster.
播出日期: 2000-09-22
运行时间: 12 min
概述: A lazy cop named Mike Bricoski lets his other fellow cops do the dirty work for him, but when he gets fired he takes his revenge out on the Powerpuff Girls.
播出日期: 2000-10-06
运行时间: 12 min
概述: Blossom and Buttercup have an argument thinking that brains or brawn is the best way to destroy a monster.
播出日期: 2000-10-06
运行时间: 12 min
概述: Mojo Jojo turns the world into dogs again. The Powerpuff Girls come to the rescue wondering why Mojo does the same plan again. He tells them that he's found a fatal flaw in his old plan as he watches a video of his old plan.
播出日期: 2000-10-20
运行时间: 12 min
概述: A dumb crook hides a jewel in a cereal box. He searches all 3000 of them and when he's down to his last one the Professor buys it for the girls'.
播出日期: 2000-10-20
运行时间: 12 min
概述: After some inspiration from their favorite comics Blossom, Bubbles, and Buttercup try to become better heroes.
播出日期: 2000-11-10
运行时间: 12 min
概述: When the Mayor rewards the Powerpuff Girls with candy for saving the day the girls ask Mojo to commit more crimes, so they can get more candy.
播出日期: 2000-11-10
运行时间: 12 min
概述: An unbeatable slime monster comes to Townsville.
播出日期: 2000-12-01
运行时间: 12 min
概述: The Mayor gets sick and tired of the Powerpuff Girls saving the day so he decides to save the day by himself.
播出日期: 2000-12-01
运行时间: 12 min
概述: The Professor sleepwalks and steals toys at the same time. When the girls' find this out they have fun taking advantage of the situation.
播出日期: 2001-01-05
运行时间: 12 min
概述: A new villain steals valuable information from smart people in Townsville, so the Powerpuff Girls use the Mayor as his new target.
播出日期: 2001-01-05
运行时间: 12 min
概述: A female villain named Femme Fatale teaches the girls' to be sexist, so she can get away with crimes.
播出日期: 2001-02-09
运行时间: 21 min
概述: The Professor tries to spend time with his daughters, but they fight crime to much. To solve the problem the Professor creates a power suit, so he could fight crime and spend time with the girls'.
播出日期: 2001-02-09
运行时间: 12 min
概述: After receiving a dollar from the Professor, Buttercup gets hooked and steals other people's teeth for the tooth fairy.
播出日期: 2001-02-09
运行时间: 12 min
概述: Mojo Jojo, Princess Morebucks, Fuzzy Lumpkins, and Him all team up as The Beat Alls to defeat the Powerpuff Girls. All is going well until Mojo Jojo falls in love with Moko Jono who breaks up the Beat Alls.
播出日期: 2001-04-03
运行时间: 12 min
概述: Bubbles loves animals and the Professor is sick of her bringing them home, but when she brings home a baby whale the girls try to hide him before the Professor comes home.
播出日期: 2001-04-03
运行时间: 12 min
概述: The Gang Green Gang raids a mini mart eating all types of foods. When the Powerpuff Girls arrive they use their heat vision which causes a chain reaction which gives the Gang Green Gang super powers.
