近未来某一年，地球爆发毁灭性极大的致命病毒，从而导致全球超过半数的人口死亡。一望无际的茫茫大海，似乎成为病毒无法涉足的神域，而汤姆·坎德勒船长（埃里克·迪恩 Eric Dane 饰）所统领的阿利·伯克级驱逐舰导弹驱逐舰“内森-詹姆斯”号，则成为天罚过后漫无目的漂流并等待 赦免的诺亚方舟。为了保存有生力量，同时确保船上的两名滤过性病原体学者研制出抗毒解药，坎德勒船长违抗了美国临时政府的召唤，带着船员踏上漫漫征途。然而一路上凶险倍至，为了补给和疫苗，他们不得不停靠港口和陆地，除此之外更有他国的船舰试图抢夺解药。更可怕的是，绝望和恐慌也在船员间蔓延。看不到未来的旅程，何日才是尽头……
末日孤舰 (季节 0)
Prequel 1: I Am Dr. Rachel Scott 0.0
播出日期: 2014-06-02
运行时间: 2 min
概述: Having just discovered a new virus that could drive man to extinction, a young doctor begins a video journal to track her progress in preventing a global pandemic.
Prequel 2: It May Pre-Date Humankind 0.0
播出日期: 2014-06-02
运行时间: 2 min
概述: Dr. Scott outlines her theory on how global warming might have exposed the modern world to an ancient virus to which we have no natural immunity.
Prequel 3: Can You Still Hear Me? 0.0
播出日期: 2014-06-09
运行时间: 2 min
概述: Dr. Scott pleads with her government benefactors for a ship to take her to the arctic so she can trace the deadly virus to its possible source.
Prequel 4: The Clock Is Ticking 0.0
播出日期: 2014-06-09
运行时间: 2 min
概述: Despite ridicule from her fellow scientists, Dr. Scott's concern over the new virus is amplified by the discovery of three new cases outside the original hot zone.
Prequel 5: Avoid Populated Areas 0.0
播出日期: 2014-06-16
运行时间: 2 min
概述: Dr. Scott shares her research with someone close to her - along with a plea to avoid populated areas - as she prepares to chase down a cure for the rapidly spreading virus.
Prequel 6: A Proper Goodbye 0.0
播出日期: 2014-06-16
运行时间: 2 min
概述: About to board the USS Nathan James, Dr. Rachel Scott imparts a final note of urgency about the threat that mankind faces, revealing that the fate of humanity hangs on the success of her mission.
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集 6