A year after the death of his friend and partner Sherlock Holmes at the hands of Moriarty, Dr. John Watson resumes his medical career as the head of a clinic dedicated to treating rare disorders. However, he soon finds that his old life is not done with him yet.
Air date: 2025-10-13
Overview: Watson and the fellows spring back into action when Mary’s mother accidentally poisons herself while suffering from a rare form of dementia that is progressing with impossible speed. Meanwhile, Sherlock Holmes resurfaces after being presumed dead.
Writer: Michael Narducci
Air date: 2025-10-20
Overview: A microbiology researcher returns from an expedition to Siberia, leading to a possible outbreak of a revived pathogen. Watson reconnects with Sherlock Holmes.
Writer: Elizabeth J.B. Klaviter
Air date: 2025-10-27
Overview: Watson and the team work alongside Laila to help a patient named Maxine, a 30-year-old who looks 10 years old.
Writer: Charly Evon Simpson
Air date: 2025-11-03
Overview: Watson and the team jump into action when four new patients are brought to UHOP with wounds that appear to be infected with a flesh-eating bacterium following a tornado. Meanwhile, Shinwell searches for meaning as a nursing student and Adam’s wedding to Lauren risks being halted.
Writer: Craig Sweeny
Air date: 2025-11-10
Overview: While visiting another hospital, Watson becomes convinced that a coma patient is suffering from locked-in syndrome and has been mistaken for a coma patient for over a decade. After the patient is transferred to UHOP for treatment, he shocks the team with chilling messages. Meanwhile, Sherlock is back in town and is staying with Watson.
Writer: Anna Mackey
Air date: 2025-11-17
Overview: Watson and the fellows race against time to save the life of Xavier, a 21-year-old athlete with a fast-growing, seemingly incurable cancer. Meanwhile, Mycroft Holmes lets Watson know his team’s work at UHOP may no longer have funding available.
Air date: 2025-11-24
Overview: Watson's father, Hamish, visits UHOP to introduce Watson and the fellows to his protégé, Annabelle, a saxophone prodigy with musically induced blackouts. As Annabelle's condition worsens, Watson must confront his long-standing tensions with his father in order to save her.
Air date: 2025-12-01
Overview: UHOP veers into terror when Watson and the fellows are taken hostage by a man with a bomb strapped to his chest who is desperate to find a cure for his 9-year-old daughter’s illness.
Air date: 2025-12-08
Overview: Watson and the fellows help Laila’s son Micah – who was injured in a car accident while pursuing his crush, Bex, with the help of his AI chatbot.
Air date: 2025-12-15
Overview: Watson’s biohacker friend Hobie returns when he rushes his new girlfriend to the Holmes Clinic after they partake in a gene-editing experiment that goes wrong. Meanwhile, Watson becomes suspicious of Sherlock.
Air date: 2026-03-01
