本片为美国时代华纳公司旗下的Cartoon Network推出的动画长篇，1998年播映了完整的动画片。位于美国的小镇村里来了一位神秘的尤教授，秉着一颗让世界更美好的心，尤教授通过科学实验，制造出了三个拥有超自然力量的完美女孩——泡泡、毛毛、花花，泡泡比较天真和乐天开朗，毛毛比较暴躁和爱美，花花则是领袖及代言人，她们三人组成了惩奸除恶的“飞天小女警”组合。在小镇村内设有专线供村民呼叫飞天小女警来寻求帮助，飞天小女警的主要任务就是与魔猴啾啾（Mojo jojo）、毛茸怪兽（Fuzzy Lumpkins）、阿米巴帮（the Amoeba boys）、“他”（Him），以及蟑螂教练等一班坏蛋们斗智斗力。
播出日期: 2001-04-14
运行时间: 21 min
概述: Him has given the girls a set of nine riddles to solve in a time limit. The various tasks test both the girls' physical and mental faculties. However, if they fail to complete them all on time, Him promises them that "the Professor will pay".
播出日期: 2001-04-20
运行时间: 21 min
概述: A sleazy director comes to Townsville to make a movie about the Powerpuff Girls.
播出日期: 2001-04-27
运行时间: 21 min
概述: Buttercup smashes Bubbles's chalk when her drawings cover the playground's blacktop. An angry Bubbles is given magic chalk by Him (disguised as a butterfly) and encouraged to express her anger in her drawings.
播出日期: 2001-05-04
运行时间: 21 min
概述: It's career day at Pokey Oaks and the Professor comes with a time machine and explains how he got into science and created the Powerpuff Girls.
播出日期: 2001-05-25
运行时间: 21 min
概述: The girls try to join the superhero organization, the Justice Friends, but they must prove themselves to do so by tests of strength, speed, and smarts. But the only flaw about the organization is it doesn't allow "little girls" into the group and it's centered around men. However, when an enemy attacks the organization, the girls must come to their rescue.
播出日期: 2001-06-01
运行时间: 21 min
概述: Microscopic rain creatures eat away at Townsville.
播出日期: 2001-06-08
运行时间: 21 min
概述: The girls find an injured squirrel and Bubbles gives it Chemical X. This creates a super powered pet squirrel.
播出日期: 2001-06-22
运行时间: 21 min
概述: Alien invaders invade Townsville, and the Powerpuff Girls go to Mojo for help.
播出日期: 2001-07-13
运行时间: 21 min
概述: The Professor's old buddy and roommate from college Dick Hardly comes for a visit. When he sees the Powerpuff Girls he comes up with a scheme to make more of them and sell them as a security system.
播出日期: 2002-05-18
运行时间: 21 min
概述: A new neighbor named Robin tries to make friends with the Powerpuff Girls, but its hard when they have to save the day all the time. Robin gets sad and makes a new friend: Princess Morebucks.
